The origin of the discovery of our Dendrogenins results from the study of tamoxifen's mode of action through functional genomics studies.
Tamoxifen has been the first drug used to treat hormone-dependent breast cancer.
During metabolic and functional genomics studies associated with the activity of this drug, an ancillary pathway for Tamoxifen which is involved in the control of cell differentiation has been identified by Dr. Marc Poirot and his scientific team at the INSERM Institute in Toulouse.
This pathway is based on serial sterol metabolism that generates molecules with original structures called Dendrogenins.
These molecules stimulate cell differentiation in the immune and nervous system and induce growth of dendrites on dendritic cell and neuron precursors.